Doctor Octopus
It would be a little difficult to do a version of Doctor Octopus that’s not directly tied to Spider-Man, but Otto Octavius is such a compelling character that there’s gotta be some way to crack it. An approach that leans into what Sam Raimi brought to the character in Spider-Man 2 would work, which is to say, making him an aspirational scientist whose ambition goes past his reach, resulting in a flawed yet deeply human character.
