Gearbox Softwareās Borderlands, while entertaining, is not perfect. From a technical standpoint anyway, things could go seriously wrong (and have) for some players, including the corrupting of character data and the resetting of hard-earned skill points.
An ongoing list of the gameās technical shortcomings, ones that may reduce you to crying or controller throwing, is being regularly updated at Gearbox Softwareās forums. Many of them appear to be tied to the gameās multiplayer cooperative mode, with incidents of players losing skills, weapon proficiencies and loot, but itās the āSave file is corruptedā issue that you should watch out for.
Gearbox has also listed a few performance hiccups that can be corrected using workarounds, should you be experiencing issues. For everyone else who has yet to jump into Borderlands and is planning on doing so, keep an eye on this thread, and tread carefully.
Known Issues Status Update [Gearbox Forums]